Mechanisms of dysfunction of the blood-brain barrier in critically ill patients: emphasis on the role of matrix metalloproteinases.

نویسندگان

  • Hugo Rojas
  • Cristiane Ritter
  • Felipe Dal Pizzol
چکیده

This paper aims to describe the physiological basis of the blood-brain barrier components and its properties. Additionally, the particular effects of metalloproteinases and their control over the extracellular matrix and its relationship with blood-brain barrier dysfunction are discussed. Finally, the role of metalloproteinases on changes in the central nervous system in critically ill patients is discussed.

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عنوان ژورنال:
  • Revista Brasileira de terapia intensiva

دوره 23 2  شماره 

صفحات  -

تاریخ انتشار 2011